Resistance to antibiotics is emerging as one of the biggest healthcare challenges of the 21st century. It endangers the lives of an increasing number of patients and threatens many of the practices of modern medicine on which we have come to rely
1.Reducing the overuse and misuse of antimi crobials, including antibiotics
2.Implementing robust prevention measures including improved cleanliness in hospitals
3.Improving surveillance and monitoring in humans and animals
4.Developing new effective treatments
Developing new classes of antibiotics that can tackle the issue of microbial resistance is a particular challenge. Over the last two decades, there have been few novel antibiotics approved by health authorities and of these a very small proportion can be identified as having a truly novel mechanism of action. Therefore, it has become increasingly important to explore ways to restore the effectiveness of antibacterial agents that were highly effective prior to the evolution of emerging resistance mechanisms. This approach is particularly appropriate for the class of β-lactam antibiotics. β-lactam antibiotics include penicillins, cephalosporins andJournal Publications
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